Precision Analytical DUTCH Testing

Key Advantages

  • Represents an entire day’s hormone production
  • Multiple day sampling available
  • Easy Sample Collection

 

DUTCH Complete Diagram

No more blood draws, spitting into tubes or filling up jugs of urine…

This advanced hormone testing was developed to surpass industry standards for available testing options. DUTCH testing offers the most extensive profile of sex and adrenal steroid hormones, along with their all-important metabolites.

The daily (diurnal) pattern of free cortisol, along with melatonin is included. This unique combination of clinical information is not available by any other testing method.

Effective HRT Monitoring

DUTCH testing was specifically made to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones.

The Easiest Patient Collection

Patients collect just four or five dried urine samples over a 24-hour period. Dried specimen samples are convenient to collect, easy to ship and stable for several weeks.

Analytical and Clinical Validation:

All Precision Analytical testing methods go through a rigorous and ongoing validation process to verify accuracy, precision, recovery, linearity, etc. in the pursuit of the most accurate and precise techniques available for hormone testing.

Validating the Concept

The DUTCH adrenal hormone test is comparable to a Saliva test in that they both reveal levels of free cortisol.

Cortisol Testing Comparison
However, the DUTCH model also provides the amount of cortisol metabolites (how much cortisol the adrenal glands are producing). Some patients may present with low free cortisol and high cortisol metabolites which means their production is high. However, the clearance of cortisol may be up-regulated making the free cortisol levels go down. Both measurements are required to show total cortisol production. Metabolites are not measured in saliva.

Do Multiple Dried Urine Sample Values Compare with Full 24-hour Urine Collections?

24 hour vs spot collection

Most Accurate Methods Used for Hormone Testing

Cortisol, cortisone and related metabolites are tested by LC-MS/MS. The remaining hormones are tested by GC-MS/MS. The most accurate methods available are used for each test. These methods show increased accuracy over the standard immunoassays used in typical serum and saliva testing.