US BioTek

Key Advantages

  • Provides unique insights into toxic chemical burden
  • Highly comprehensive
  • Provides synergistic partnership with UMP testing

Introduction

Chronic exposure to a number of occupational and environmental pollutants is a growing concern in today’s industrialised communities: their effects on human health are profound.

US BioTek Laboratories’ Environmental Pollutants Profile quantifies exposure to select environmental toxins: aromatic solvents, paraben and phthalates.

Widespread Toxins

Many environmental pollutants have been linked to a variety of pathologies including neuropsychological and neuropsychological dysfunction, leukopenia, dyspnea, anaemia, and certain cancers, to name a few.

Acute toxicological effects of aromatic compounds include nausea, vomiting, abdominal pain, headache, dizziness, drowsiness, confusion, tremor, and loss of consciousness. Chronic exposure may affect multiple organ systems.

Aromatic solvents are used commercially in a variety of applications. You’ll find them in the manufacture of plastics, paints, varnishes, resins, synthetic fibers, rubbers, lubricants, dyes and detergents. They are also used in the printing and leather industries, found in many industrial cleaning agents and are a natural part of gasoline, airplane fuel and cigarette smoke.

Parabens are a widely used family of preservatives found in many cosmetic, pharmaceutical and industrial products. They have inherent estrogenic, and other hormone related activity, and have been detected in certain human breast cancer cell lines.

Phthalates are used in the manufacture of plastics to allow for flexibility. They are found in everything from makeup to detergents, shampoos to time-released pharmaceutical drugs. Phthalic acid esters are well known endocrine disruptors which may cause neurological and developmental disorders. They can interfere with tryptophan metabolism resulting in an increase in quinolinic acid, a pro-inflammatory and neurotoxic compound. Phthalates have also been implicated in abnormal foetal development, especially in male foetuses.

The physiological effects from exposure to these toxins depend on a number of factors. These include the amount and duration the individual is exposed to the substance, the route of exposure (air, water, food, skin, consumer products), and whether or not other chemicals are present at the time of exposure, as some compounds exert an accumulated effect.

The Results

A patient-friendly report flags abnormal values against a population ranking. A quick reference guide of possible sources of exposure is also provided.

Chemicals in the report include metabolites of xyelene, toluene, benzene, trimethybenzene, styrene, paraben, and phthalate.

The metabolites of these parent compounds are measured from a first morning spot urine specimen. This is collected using a proprietary urine Dip ’N Dry collection strip, which provides maximised analyte stability and recovery.

Test Description:

A quantitative GC/MS analysis for the assessment of aromatic solvent metabolites, phthalate metabolites, and parabens in urine.

Analytes:

  • Benzene Metabolites: t,t -Muconic Acid
  • Miscellaneous: Quinolinate
  • Paraben Metabolites: Para-Hydroxybenzoate
  • Phthalate Metabolites: Monoethyl Phthalate, Phthalic Acid
  • Styrene Metabolites: Mandelate, Mandelate + Phenylglyoxylate, Phenylglyoxylate
  • Toluene Metabolites: Hippurate
  • Trimethylbenzene Metabolites: 3,4-Dimethylhippurate
  • Xylene Metabolites: 2-Methylhippurate, 3-Methylhippurate

Resources

Resources
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