Why 24 hour Urine Hormones?
Hormones are made and released by cells of the endocrine glands. These “chemical messengers” are generally released in short bursts or pulses at various intervals reflecting physical and mental status in addition to circadian variations. A 24-hour urine sample offers the most sensitive means to account for the production and metabolic activity of steroid hormones against the natural variations that we see in a 24-hour period. Steroid hormones are transported by the blood to various target cells on which they have specific effects. The circulating form in the bloodstream is bound almost entirely to various plasma proteins. Urine sampling provides the best indicator of the free or unbound steroid; the biologically active form.
Steroid hormones in urine are present as either free (trace quantities) or conjugate form that must undergo quantitative hydrolysis. The refined assay methodology retains steroid structure and constitution for maximum recovery through gas chromatography-mass spectrometry (GC/MS); the method of choice for accurate steroid measurement.
Epidemiological data support the role for some steroid hormones in excess or deficiency, in the pathogenesis of certain cancers including that of the breast, uterine endometrium, prostate, testis and ovary. Cancer results from a complex interaction between age, genetics and environmental factors. Tissue biopsy and imaging confirms such diagnoses. Urine steroid hormone measurements provide insights into current hormone metabolism (not merely their level/s) which has been shown to correlate with varying degrees of Cancer risk.
Adrenal Steroidal Sufficiency
The adrenal hormones include cortisol and DHEA. The hormones of the gonads, known as sex hormones, include estrogens, progesterone and testosterone. These steroid hormones and their metabolites are the foundation of the Comprehensive Urinary Hormone Profile.
Hormone testing is primarily used to identify hormone deficiencies and excess. The Comprehensive Urinary Steroid Hormone Profile provides data for over 30 key analytes serving as markers for major androgens, estrogens, progesterone and metabolites, and adrenal hormones and metabolites.
The levels of many hormones and their metabolites may fluctuate throughout the course of a day reflecting physical and mental status. A 24-hour urine sample offers the most sensitive means to account for these natural daily variations.
Optimal hormone levels may vary from person to person but should be within a range that allows the individual relief from complaints and problems suggestive of a hormone deficiency or excess. Assessment and treatment is under the guidance of a physician who may interpret test results against information also gained from a thorough physical exam and interview.
40+ Markers Tested