Estrogen Dominance: When an unhealthy Gut Estrobolome is to blame
Carrie Jones, ND, MPH
It is well established that elevated estrogen can pose many problems for both men and women. Not only can it result in estrogen dominance symptoms; if not properly detoxified, it increases the risk of several cancers. When patients present with elevated laboratory levels of estrogen and/or have symptoms related to excess estrogen, strategies often include supplements such as diindolylmethane (DIM) or indole-3-carbinol (I3C). While DIM and I3C can be effective at lowering estrogen levels, they only impact phase-1 of estrogen metabolism. Frequently overlooked are the phase-2 and -3 processes that play major roles in the safe excretion of this hormone. It is critical to consider all phases of metabolism, including the intestinal microbiome’s important role in facilitating proper excretion of estrogen metabolites; impairments in this step can have a significant effect on the patient’s health. By having a clearer understanding of each step and making sure to focus on proper gut health, practitioners can help mitigate potential risks in the future.
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