What’s the Deal with Cortisol? Assessing Patients Using the Cortisol Awakening Response (CAR)
The circadian rhythm influences many factors in the human body, including sleep-wake cycles, hormone production and release, hunger and satiety, mood, digestion, the immune system, and body temperature. As such, any dysfunction within this process increases the risk for long-term sequelae and chronic disease.
- Contreras C and Gutierrez-Garcia A. Cortisol Awakening Response: An Ancient Adaptive Feature. Journal of Psychiatry and Psychiatric Disorders 2 (2018): 29-40.
- Ennis GE, Moffat SD, Hertzog C. The cortisol awakening response and cognition across the adult lifespan. Brain and cognition. 2016; 105:66-77. [pubmed]
- Rocamora-Reverte L, et al. T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites. Cell Death & Disease. 2017;(8): https://doi.org/10.1038/cddis.2017.344
- Sephton SE. Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival. 2000; 92(12):994-1000.
- Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. Endocrine reviews. 2018; 39(4):489-517. [pubmed]
Taff CC, Vitousek MN. Endocrine Flexibility: Optimizing Phenotypes in a Dynamic World? Trends in Ecology & Evolution. 2016; 31(6):476-488
- Powell DJ, Schlotz W. Daily life stress and the cortisol awakening response: testing the anticipation hypothesis. PloS one. 2012; 7(12):e52067. [pubmed]