P88 - Dietary Antigen Test (Serum)

P88 – Dietary Antigen Test (Serum)

Sample Required: Serum | Test Type: Nutrition

Key Advantages

IgE (Immunoglobulin E)
IgG4 (Immunoglobulin G – subtype 4)
Displays IgE in Relation to IgG4 (‘Blocking Potential’) for Each Food Group

RESOURCES

Sample Report

The P88 is a Dietary Antigen Test that combines IgE, IgG, IgG4 and complement (C3d) reactions to 88 common foods in the diet. Offering for the most comprehensive look at dietary antigen activity. The P88 Dietary Antigen Test was one of the first tests on the market to measure and report immune complexes containing C3d. Complement activation is well-defined in the research as not only a cause of inflammation but being one of the strongest causes.

Better client outcomes

P88 Dietary Antigen Test results may assist in ensuring treatment plans are more precise and help improve patient outcomes. Studies have shown that when patients have been given an elimination diet based on the results of the P88 food allergy and sensitivity test, many experienced less abdominal pain, diarrhoea, constipation, and bloating as well as fewer headaches. Knowing exactly what foods your patient reacts to can help to avoid unnecessary restrictive diets and treatment protocols that may have inadvertently exposed your patient to his or her reactive foods.

The P88 Dietary Antigen Test interpretive report includes more restrictive and less restrictive elimination diets as well as an analysis of immune reactions by specific food groups. This customized report not only helps the clinician use at-a-glance results in clinical practice but also better ensures patient compliance (see sample report). The P88 Dietary Antigen Test may be the missing piece of the puzzle and may lead to the resolution of previously resistant health problems.

IgE (Immunoglobulin E)

The IgE antibody response is the most commonly known food allergy response. This response usually occurs immediately and can create severe symptoms such as swelling, hives, itching, and – in some cases – anaphylaxis.

Even though IgE reactions are immediate, the allergic potential of food-based allergens can remain in the system 1-2 days after ingestion, extending the presence of symptoms during this duration. IgE reactions can be permanent or they may improve with the elimination diet and gut treatment. IgE reactions stimulate the release of Histamine in the body.

IgG4 (Immunoglobulin G – subtype 4)

IgG4, which is a subclass of IgG, is another antibody in the immune system. IgG4 blocks IgE antibodies from binding to receptor sites and releasing histamine. During treatment, when an allergist gives injections for desensitization, it is to increase IgG4 to block IgE, not to lower IgE. When the qualitative amount of IgG4 is higher than IgE, it creates a blocking effect and keeps the IgE from causing anaphylaxis.

The presence of this blocking agent assists your practitioner in diagnosis and treatment by helping to determine the severity of your reaction to certain foods.

Summary

In addition to listing the individual IgE & IgG4 responses to each food, the report also groups the results into food groups, displaying their IgE and IgG4 readings in graphical form.
At very high levels, IgG4 antibodies alone can trigger an immune response within the body themsleves.
However, data is available that provides support for the notion that IgG4 can serve another specific function of controlling IgE antigen recognition and consequently regulating anaphylatic reactions and IgE-mediated immunity.
IgG4 can act as a blocking agent by preventing IgE from binding to targeted receptor sites and releasing histamine. This is referred to as the blocking potential.

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