Pioneers in Health. Science. Genetics.

Creating better health through science and genetics, empowering patients with knowledge and support of underlying issues, allowing them to gain back control of their health and live their best lives

MTHFR Support Australia was founded in 2013 by Carolyn Ledowsky in response to a patient demand to address health issues specifically relating to key genes in the methylation cycle.

It is this cycle that is responsible for key biochemical pathways that support our mood, sleep, digestion, hormones, energy and detoxification capacity.

How do you know if you have a methylation problem?

Methylation is one of the most important biochemical processes in the human body. It impacts all areas of our body’s normal functioning, from heart health to fertility, detoxification, immune health and brain function. If you are experiencing long-term or chronic health issues, your methylation (or lack of) may be contributing to your symptoms.

What is MTHFR?

MTHFR is a gene, which produces the MTHFR (methylenetetrahydrofolate reductase) enzyme and is considered a key enzyme in one-carbon metabolism because it catalyses the irreversible conversion of 5,10-methylene THF to 5-methyl tetrahydrofolate.1 5-MTHF is our active folate that is then used in the methylation cycle.

What is Methylation?

Methylation or one-carbon metabolism is a network of interrelated biochemical pathways for reduction or oxidation and transfer to other compounds. This allows the transfer of a methyl group (one carbon and three hydrogen atoms) onto amino acids, proteins, enzymes and DNA in every cell and tissue of the body. This regulates healing, produces energy, genetic expression of DNA, synthesises neurotransmitters, liver detoxification, immunity and hormonal clearance. So disturbances in this methylation pathway can have significant and widespread effects on many body systems.

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